Description
Factor XIII (FXIII) cross-links fibrin upon activation by thrombin. Activation involves cleavage at residue 37 by thrombin, releasing an activation peptide. A common polymorphism (valine to leucine variant at residue 34, V34L), located in the activation peptide, has been associated with increased activation rates and paradoxically a protective effect in cardiovascular disease.
Variants Tested
F13A1 c.103G>T; p.Val34Leu.
Test code(s)
BMG-314
TAT
5 business days
Method
Polymerase chain reaction (PCR)
Accepted Sample requirements
EDTA Blood, DNA