Description
: For non-deletional α-thalassemia, Sanger DNA sequencing can be used to detect all point mutations. Allele-specific PCR also has a role in areas where certain mutations are common, such as hemoglobin Constant Spring in Southeast Asia. DNA analysis of the common α-globin gene deletions performed by multiplex polymerase chain reaction (PCR) followed by agarose gel electrophoresis may, on occasion, be used for confirmatory purposes.
Method
Polymerase chain reaction (PCR)
TAT
5 business days
Accepted Sample requirements
EDTA Blood, DNA