Pharmacogenetic (PGX) Testing analyzes how an individual’s genetic makeup influences their response to medications. By identifying specific genetic variations, particularly in genes responsible for drug metabolism, transport, and targets, PGX testing helps guide personalized treatment plans. This allows healthcare providers to optimize drug selection and dosage, reducing the risk of adverse drug reactions and enhancing therapeutic efficacy.
For example, variations in CYP450 enzymes (such as CYP2D6 and CYP3A4) can significantly impact how patients metabolize medications. These variations may cause a patient to metabolize drugs too quickly, too slowly, or not at all, which can require adjustments in treatment to achieve the best clinical outcomes.
Pharmacogenetic testing aims to enhance drug efficacy, reduce side effects, and support healthcare providers in making informed treatment decisions based on the patient’s unique genetic profile.