Test name

EGFR. Sequencing of the exons 18, 19, 20 and 21

Purpose of the test

This is a clinical test intended for : Diagnosis

Condition

1 condition tested.

Lung cancer

Methodology

Molecular Genetics

Sequence analysis of select exons

Bi-directional Sanger Sequence Analysis

Test services

Clinical Testing/Confirmation of Mutations Identified Previously

Clinical summary

Lung cancer is the leading cause of cancer deaths in the U.S. and worldwide. The 2 major forms of lung cancer are nonsmall cell lung cancer and small cell lung cancer (see 182280), which account for 85% and 15% of all lung cancers, respectively. Nonsmall cell lung cancer can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. Cigarette smoking causes all types of lung cancer, but it is most strongly linked with small cell lung cancer and squamous cell carcinoma. Adenocarcinoma is the most common type in patients who have never smoked. Nonsmall cell lung cancer is often diagnosed at an advanced stage and has a poor prognosis (summary by Herbst et al., 2008).

Clinical features

Alveolar cell carcinoma

Conditions tested

Condition/Phenotype	Also known as	Identifier
Lung cancer	Lung cancer, somatic	IM:211980, C0684249

Target population

Individuals with clinical symptoms consistent with disorder/disease

Analytical Validity

For Sanger sequencing, according our cumulative experience and proficiency tests, the error rate is less than 0.01% (99.99% accuracy)