Allele specific PCR for HLA-B27 is a direct genotyping method based on specific primer recognition of a unique HLA-B27 gene sequence. It uses HLA-B27 unique primer specific for HLA-B alleles.

What does a positive HLA-B27 test mean?

A positive test means HLA-B27 is present. It suggests a greater-than-average risk for developing or having certain autoimmune disorders. An autoimmune disorder is a condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue.

What disease is related to HLA-B27 positive?

Although associated with spondylarthritis, the pathologic role of this allele in immune dysregulation remains under investigation. With lower frequency, the presence of the HLA-B27 allele has correlated with inflammatory bowel disease, psoriatic arthritis, and reactive arthritis.

What immune disorders are HLA-B27?

People with HLA-B27 have an increased likelihood of developing autoimmune diseases such as ankylosing spondylitis (AS), juvenile rheumatoid arthritis (JRA), reactive arthritis (of which one subset is Reiter syndrome), and isolated acute anterior uveitis.